Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2

"key as to OAS “Viral variant infection elicits variant-specific antibodies, but prior mRNA vaccination imprints serological responses toward Wuhan-Hu-1 rather than variant antigens.” This is OAS and simply put, it is a prime or bias or prejudice or imprinting whereby the initial immune response will be the response to that original antigen or similar, with future exposures."

Röltgen et al. “Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination”; this study is key; shows original antigenic sin (OAS) (substack.com)

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